Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands
Identifieur interne : 000616 ( Main/Exploration ); précédent : 000615; suivant : 000617Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands
Auteurs : Nicky G F M. Beukers [Pays-Bas] ; Geert J M G. Van Der Heijden [Pays-Bas] ; Arjen J. Van Wijk [Pays-Bas] ; Bruno G. Loos [Pays-Bas]Source :
- Journal of Epidemiology and Community Health [ 0143-005X ] ; 2016.
Abstract
The association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and ACVD among all individuals registered in a large dental school in the Netherlands (Academic Centre for Dentistry Amsterdam (ACTA)).
Anonymised data were extracted from the electronic health records for all registered patients aged >35 years (period 1998–2013). A participant was recorded as having periodontitis based on diagnostic and treatment codes. Any affirmative answer for cerebrovascular accidents, angina pectoris and/or myocardial infarction labelled a participant as having ACVD. Other risk factors for ACVD, notably age, sex, smoking, diabetes, hypertension, hypercholesterolaemia and social economic status, were also extracted. Logistic regression analyses were used to evaluate the adjusted associations between periodontitis and ACVD.
60 174 individuals were identified; 4.7% of the periodontitis participants (455/9730) and 1.9% of the non-periodontitis participants (962/50 444) reported ACVD; periodontitis showed a significant association with ACVD (OR 2.52; 95% CI 2.3 to 2.8). After adjustment for the confounders, periodontitis remained independently associated with ACVD (OR 1.59; 95% CI 1.39 to 1.81). With subsequent stratification for age and sex, periodontitis remained independently associated with ACVD.
This cross-sectional analysis of a large cohort in the Netherlands of 60 174 participants shows the independent association of periodontitis with ACVD.
Url:
DOI: 10.1136/jech-2015-206745
PubMed: 27502782
PubMed Central: 5256268
Affiliations:
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Van Wijk</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Public Oral Health</addr-line>,<institution>Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Bruno G" sort="Loos, Bruno G" uniqKey="Loos B" first="Bruno G" last="Loos">Bruno G. 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Beukers</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Periodontology</addr-line>,<institution>Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Heijden, Geert J M G" sort="Van Der Heijden, Geert J M G" uniqKey="Van Der Heijden G" first="Geert J M G" last="Van Der Heijden">Geert J M G. Van Der Heijden</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Public Oral Health</addr-line>,<institution>Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Wijk, Arjen J" sort="Van Wijk, Arjen J" uniqKey="Van Wijk A" first="Arjen J" last="Van Wijk">Arjen J. Van Wijk</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Public Oral Health</addr-line>,<institution>Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Bruno G" sort="Loos, Bruno G" uniqKey="Loos B" first="Bruno G" last="Loos">Bruno G. Loos</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Periodontology</addr-line>,<institution>Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Epidemiology and Community Health</title><idno type="ISSN">0143-005X</idno><idno type="eISSN">1470-2738</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and ACVD among all individuals registered in a large dental school in the Netherlands (Academic Centre for Dentistry Amsterdam (ACTA)).</p></sec><sec><title>Methods</title><p>Anonymised data were extracted from the electronic health records for all registered patients aged >35 years (period 1998–2013). A participant was recorded as having periodontitis based on diagnostic and treatment codes. Any affirmative answer for cerebrovascular accidents, angina pectoris and/or myocardial infarction labelled a participant as having ACVD. Other risk factors for ACVD, notably age, sex, smoking, diabetes, hypertension, hypercholesterolaemia and social economic status, were also extracted. Logistic regression analyses were used to evaluate the adjusted associations between periodontitis and ACVD.</p></sec><sec><title>Results</title><p>60 174 individuals were identified; 4.7% of the periodontitis participants (455/9730) and 1.9% of the non-periodontitis participants (962/50 444) reported ACVD; periodontitis showed a significant association with ACVD (OR 2.52; 95% CI 2.3 to 2.8). After adjustment for the confounders, periodontitis remained independently associated with ACVD (OR 1.59; 95% CI 1.39 to 1.81). With subsequent stratification for age and sex, periodontitis remained independently associated with ACVD.</p></sec><sec><title>Conclusions</title><p>This cross-sectional analysis of a large cohort in the Netherlands of 60 174 participants shows the independent association of periodontitis with ACVD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pihlstrom, Bl" uniqKey="Pihlstrom B">BL Pihlstrom</name></author><author><name sortKey="Michalowicz, Bs" uniqKey="Michalowicz B">BS Michalowicz</name></author><author><name sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laine, Ml" uniqKey="Laine M">ML Laine</name></author><author><name sortKey="Crielaard, W" uniqKey="Crielaard W">W Crielaard</name></author><author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Bray</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Beukers, Nicky G F M" sort="Beukers, Nicky G F M" uniqKey="Beukers N" first="Nicky G F M" last="Beukers">Nicky G F M. Beukers</name></noRegion><name sortKey="Loos, Bruno G" sort="Loos, Bruno G" uniqKey="Loos B" first="Bruno G" last="Loos">Bruno G. Loos</name><name sortKey="Van Der Heijden, Geert J M G" sort="Van Der Heijden, Geert J M G" uniqKey="Van Der Heijden G" first="Geert J M G" last="Van Der Heijden">Geert J M G. Van Der Heijden</name><name sortKey="Van Wijk, Arjen J" sort="Van Wijk, Arjen J" uniqKey="Van Wijk A" first="Arjen J" last="Van Wijk">Arjen J. Van Wijk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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